INDIANAPOLIS — Indianapolis Colts wide receiver Reggie Wayne made sure his 200th regular-season game meant something.

Wayne caught seven passes for 119 yards Sunday at Lucas Oil Stadium and was one of four Colts players to catch touchdown passes in a 41-17 win over the struggling Tennessee Titans.

Wayne moved into the top 10 on the NFL’s all-time receiving yards list, passing Henry Ellard, and moved into seventh place in all-time pass catches. He has 1,029 catches for 13,875 yards.

When Wayne caught a 28-yard pass from quarterback Andrew Luck in the third quarter to give the Colts a 27-10 lead, Lucas Oil Stadium exploded with chants of “Reggie, Reggie, Reggie.”

Luck completed 29-of-41 passes for 393 yards and four touchdowns. He was intercepted once.

The victory was the ninth straight in AFC South play for the Colts (2-2), dating back to 2012.

The Titans (1-3) have lost three straight games after winning their season opener against Kansas City.

Tennessee quarterback Charlie Whitehurst got his first start since 2011, completing 12-of-23 passes for 177 yards and a touchdown to tight end Delanie Walker. Whitehurst started in place of Jake Locker, who was out with a wrist injury. With the Titans down 41-17 in the fourth quarter, Whitehurst was replaced by Zach Mettenberger.

In addition to Wayne, Luck threw touchdown passes to tight ends Dwayne Allen (seven yards) and Coby Fleener (2), and running back Ahmad Bradshaw (15).

The Colts, taking advantage of two Tennessee turnovers, scored on four of their first five possessions to take a 20-3 lead in the second quarter. Running back Trent Richardson scored from one yard out with 7:06 left in the opening quarter to put the Colts in front, 7-0.

A surprise onside kick on the following kickoff was recovered by Indianapolis wide receiver Griff Whalen and set up an 11-play, 44-yard scoring drive that finished with a 7-yard scoring pass from Luck to Allen.

NOTES: Titans QB Jake Locker did not play because of a wrist injury that happened in last week’s game against Cincinnati. Locker did not practice last week and was placed on Tennessee’s inactive list. … Also out was Titans DE Ropati Pitoitua. He was replaced by Mike Martin. … Colts WR Reggie Wayne played in his 200th career regular-season game Sunday. He is the third player in Colts history to reach that mark, joining QB Johnny Unitas and QB Peyton Manning. … Colts QB Andrew Luck has 13 touchdown passes in his first four games, passing the franchise best (11 in 2004 and 2010) held by Peyton Manning. … Colts K Adam Vinatieri has not missed a field goal this season, converting all eight of his attempts, including from 31 and 30 yards Sunday.